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Ruserontinib

CAT: 0804-HY-120590-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120590-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ruserontinib (SKLB1028) is an orally active multikinase inhibitor of EGFR, FLT3 and Abl, with an IC50 value of 55 nM for human FLT3, and has antitumor activity[1].
CAS Number
1350544-93-2
Product Name Alternative
SKLB1028
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bcr-Abl; EGFR; FLT3
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ruserontinib.html
Purity
99.32
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4N=C(N(C4=N3)C(C)C)NC5=CC=CN=C5
Molecular Formula
C24H29N9
Molecular Weight
443.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Z-X Cao, et al. SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable potency in models of CML harboring Abl mutants. Leukemia. 2012 Aug;26 (8) :1892-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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CatalogName
A8971-5Ruserontinib

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