Products for Research Use Only
RegisterLogin

ZCL278

CAT: 0804-HY-13963-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13963-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ZCL278 is a selective Cdc42 inhibitor with Kds of 6.4 μM in fluorescence titration and 11.4 μM in surface plasmon resonance (SPR) measurement. ZCL278 is able to disrupt the Cdc42-ITSN interaction as well as GTP/GDP binding. ZCL278 has inhibitory effects on various enveloped viruses, but is ineffective against non-enveloped viruses. ZCL278 can be used for the studies of arsenic neurotoxicity and HER2-positive gastric cancer (GC) [1][2][3][4].
CAS Number
587841-73-4
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Arenavirus; Dengue Virus; Ras; VSV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ZCL278.html
Purity
98.49
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC(NC1=CC=C(S(=O)(NC2=NC(C)=CC(C)=N2)=O)C=C1)=S)COC3=CC=C(Br)C=C3Cl
Molecular Formula
C21H19BrClN5O4S2
Molecular Weight
584.89
Precautions
H302, H410
References & Citations
[1]Friesland A, et al. Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc Natl Acad Sci U S A. 2013 Jan 22;110 (4) :1261-6.|[2]Chou YY, et al. Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol. 2016 Apr 14;90 (9) :4494-510.|[3]An Y, Liu T, Liu X, Zhao L, Wang J. Rac1 and Cdc42 Play Important Roles in Arsenic Neurotoxicity in Primary Cultured Rat Cerebellar Astrocytes. Biol Trace Elem Res. 2016 Mar;170 (1) :173-82. |[4]Liang B, et al. Cdc42-driven endosomal cholesterol transport promotes collateral resistance in HER2-positive gastric cancer. Cancer Lett. 2024 Apr 10;587:216702.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-170327-01ZCL279

Alternative Products

CatalogName
A8300-10ZCL278
bs-60133C-01ZCL278 --- Cdc42 GTPase Inhibitor
217262CDC42 Inhibitor III, ZCL278 (4- (3- (2- (4-Bromo-2-chloro-phenoxy) -acetyl) -thioureido) -N- (4,6-dimethyl-pyrimidin-2-yl) -benzenesulfonamide, 2- (4-Bromo-2-chlorophenoxy) -N- ((4- ((4,6-dimethyl-2-pyrimidinyl) sulfamoyl) phenyl) carbamothioyl) acetamide, CDC42 GTPase Inhibitor III)

Popular Products