Paprotrain

CAT: 0804-HY-101298-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-101298-02Size:10 mM - 1 mL

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Description

Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.

CAS Number

57046-73-8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Kinesin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Paprotrain.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : ≥ 100 mg/mL

Smiles

N#C/C(C1=CNC2=CC=CC=C21)=C\C3=CN=CC=C3

Molecular Formula

C16H11N3

Molecular Weight

245.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Labrière C, et al. Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors. Eur J Med Chem. 2016 Nov 29;124:920-934.|[2]Liu J, et al. MKlp2 inhibitor paprotrain affects polar body extrusion during mouse oocyte maturation. Reprod Biol Endocrinol. 2013 Dec 21;11:117.|[3]Zhang Y, et al. KIF20A regulates porcine oocyte maturation and early embryo development.|[4]Tcherniuk S, et al. Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew Chem Int Ed Engl. 2010 Oct 25;49 (44) :8228-31.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Kinesin-6

Chemical Information

Paprotrain

CAS Number	57046-73-8
PubChem CID	12248889
IUPAC Name	(Z)-2-(1H-indol-3-yl)-3-pyridin-3-ylprop-2-enenitrile
Molecular Formula	C16H11N3
Molecular Weight	245.28
XLogP	2.8
Topological Polar Surface Area	52.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Heavy Atom Count	19
Formal Charge	0
Complexity	392

SMILES

C1=CC=C2C(=C1)C(=CN2)/C(=C/C3=CN=CC=C3)/C#N

InChI

InChI=1S/C16H11N3/c17-9-13(8-12-4-3-7-18-10-12)15-11-19-16-6-2-1-5-14(15)16/h1-8,10-11,19H/b13-8+

InChIKey

YMYYQRZCCKBFBE-MDWZMJQESA-N

Chemical Structure

2D Structure

CAS: 57046-73-8

CID: 12248889

Formula: C16H11N3

MW: 245.28

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	245.28
XLogP3	2.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	245.095297364
Monoisotopic Mass	245.095297364
Topological Polar Surface Area	52.5 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	392
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

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T12359-01	Paprotrain
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A20346-25	Paprotrain 25mg
A20346-500	Paprotrain 500mg
A20346-50	Paprotrain 50mg
A20346-10	Paprotrain 10mg
A20346-100	Paprotrain 100mg

Paprotrain

Chemical Information

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