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Phaclofen

CAT: 0804-HY-100798-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100798-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phaclofen is a selective GABAB receptor antagonist. Phaclofen is a peripheral and central baclofen antagonist. Phaclofen maybe a potential compound in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-) -baclofen interact[1][2].
CAS Number
114012-12-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/phaclofen.html
Purity
99.98
Solubility
1M NaOH : 50 mg/mL (ultrasonic) |DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=CC=C(C(CN)CP(O)(O)=O)C=C1
Molecular Formula
C9H13ClNO3P
Molecular Weight
249.63
Precautions
H315, H319, H335
References & Citations
[1] Johnson CM, et al. The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release. Neuropharmacology. 2020;176:108214.|[2]Kerr DI, et al. Phaclofen: a peripheral and central baclofen antagonist. Brain Res. 1987;405 (1) :150-154.|[3]Wüllner U, et al. Phaclofen antagonizes the depressant effect of baclofen on spinal reflex transmission in rats. Brain Res. 1989;496 (1-2) :341-344.|[4]Chen SH, et al. Changes in GABA and GABA (B) receptor expressions are involved in neuropathy in the rat cuneate nucleus following median nerve transection. Synapse.2012; 66 (6) :561-572.|[5]Abellán MT, et al. Dual control of dorsal raphe serotonergic neurons by GABA (B) receptors. Electrophysiological and microdialysis studies. Synapse. 2000;36 (1) :21-34.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
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