BN82002 (hydrochloride)

BN82002 (hydrochloride)

• CAS Number: 1049740-43-3
• UNSPSC Description: BN82002 hydrochloride is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. BN82002 hydrochloride inhibits CDC25A, CDC25B2, CDC25B3, CDC25C CDC25A, and 25C-cat with IC50 values of 2.4, 3.9, 6.3, 5.4, and 4.6 μM, respectively. BN82002 hydrochloride displays ~20-fold greater selectivity over CD45 tyrosine phosphatase[1].
• Target Antigen: Phosphatase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bn82002-hydrochloride.html
• Purity: 99.36
• Solubility: DMSO : 220 mg/mL (ultrasonic)
• Smiles: O=[N+]([O-])C1=CC=C(CCN(CC2=CC(N(C)C)=CC(OC)=C2O)C)C=C1.Cl
• Molecular Weight: 395.88
• References & Citations: [1]Brezak MC, et al. A novel synthetic inhibitor of CDC25 phosphatases: BN82002. Cancer Res. 2004 May 1;64(9):3320-5.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported