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Guaiazulene

CAT: 0804-HY-N6951-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6951-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Guaiazulene is a bicyclic sesquiterpene that can cross the blood-brain barrier. Guaiazulene exhibits various biological activities such as anti-inflammatory, antioxidant, hepatoprotective, antibacterial, and anti-tumor properties. Guaiazulene is also commonly used as a colorant in cosmetics. Guaiazulene shows in vitro cytotoxicity to rat neuronal cells and N2a neuroblastoma cells at high concentrations[1][2][3][4].
CAS Number
489-84-9
UNSPSC
12352005
Hazard Statement
H302
Target
Akt; Apoptosis; Bacterial; Caspase; Fungal; mTOR; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/guaiazulene.html
Concentration
10mM
Purity
99.26
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C1=CC2=C(C)C=CC2=C(C)C=C1)C
Molecular Formula
C15H18
Molecular Weight
198.30
Precautions
H302
References & Citations
[1]Kourounakis AP, et al. Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats. J Pharm Pharmacol. 1997 Sep;49 (9) :938-42.|[2]Togar B, et al. Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells. J Intercult Ethnopharmacol. 2015 Jan-Mar;4 (1) :29-33.|[3]Akram W, et al. Guaiazulene and related compounds: A review of current perspective on biomedical applications. Life Sci. 2023 Mar 1;316:121389.|[4]Ye Q, et al. Guaiazulene Triggers ROS-Induced Apoptosis and Protective Autophagy in Non-small Cell Lung Cancer. Front Pharmacol. 2021 Apr 15;12:621181.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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