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Basroparib

CAT: 0804-HY-147245-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147245-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Basroparib (STP1002) is a selective, orally active inhibitor of tankyrase (TNKS1/TNKS2) with IC50 of 29.94 nM and 3.68 nM for TNKS1 and TNKS2, respectively. Basroparib has an IC50 of >10 μM for PARP1. Basroparib binds to TNKS, stabilizes AXIN1/2 proteins, blocks Wnt/β-catenin signaling pathway, inhibits tumor cell proliferation and induces apoptosis, while reducing cancer stem cell properties. Basroparib can be used in colorectal cancer (CRC) studies with KRAS mutations (such as G12V/G12D) to overcome acquired resistance to MEK inhibitors. STP1002 has synergistic antitumor activity with MEK inhibitors[1][2][3].
CAS Number
1858179-75-5
Product Name Alternative
STP1002
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/basroparib.html
Purity
98.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N=C(N2CCN(CC2)C3=C(C=C(C=C3F)OCCOC)F)NC4=C1N=NN4C
Molecular Formula
C18H21F2N7O3
Molecular Weight
421.40
References & Citations
[1]Kwon YJ, et al. Basroparib overcomes acquired resistance to MEK inhibitors by inhibiting Wnt-mediated cancer stemness in KRAS-mutated colorectal cancer. Biochem Pharmacol. 2025 May;235:116842.|[2]Kim, Uk-Il, et al. Formulation development of basroparib as a first-in-class tankyrase inhibitor using a microprecipitated bulk powder approach. Journal of Pharmaceutical Investigation (2025) : 1-11.|[3]Bai YR, et al. The recent advance and prospect of poly (ADP-ribose) polymerase inhibitors for the treatment of cancer. Med Res Rev. 2024 Aug 24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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