M-PEG4-Boc

• Description :

  M-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

• UNSPSC :

  12352203

• Hazard Statement :

  H315-H319

• Target :

  ADC Linker; PROTAC Linkers

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/m-peg4-boc.html

• Purity :

  98.0

• Solubility :

  10 mM in DMSO

• Smiles :

  COCCOCCOCCOCCC(OC(C)(C)C)=O

• Molecular Formula :

  C14H28O6

• Molecular Weight :

  292.37

• Precautions :

  P264-P280-P302+P352-P362+P364

• References & Citations :

  [1]Hervé Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1.|[2]Peter Madsen, et al. Protease stabilized, pegylated insulin analogues. WO2009010428A1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker; PEG Linkers

• CAS Number :

  [883554-11-8]