Sinefungin

• Description :

  Sinefungin is a potent inhibitor of virion mRNA (guanine-7-) -methyltransferase, mRNA (nucleoside-2'-) -methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].

• Product Name Alternative :

  Adenosyl-Ornithine; A-9145; Antibiotic 32232RP

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Antibiotic; Fungal; Histone Methyltransferase; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Epigenetics

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/sinefungin.html

• Purity :

  99.79

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles :

  O[C@H]([C@@H]1O)[C@@H](O[C@@H]1C[C@@H](N)CC[C@H](N)C(O)=O)N2C(N=CN=C3N)=C3N=C2

• Molecular Formula :

  C15H23N7O5

• Molecular Weight :

  381.39

• Precautions :

  H302

• References & Citations :

  [1]Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA (guanine-7-) -methyltransferase, mRNA (nucleoside-2'-) -methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253 (12) :4075-7.|[2]Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27 (1) :203-15.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [58944-73-3]