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Sinefungin

CAT: 0804-HY-101938-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101938-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sinefungin is a potent inhibitor of virion mRNA (guanine-7-) -methyltransferase, mRNA (nucleoside-2'-) -methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].
CAS Number
58944-73-3
Product Name Alternative
Adenosyl-Ornithine; A-9145; Antibiotic 32232RP
UNSPSC
12352005
Hazard Statement
H302
Target
Antibiotic; Fungal; Histone Methyltransferase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sinefungin.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@H]([C@@H]1O)[C@@H](O[C@@H]1C[C@@H](N)CC[C@H](N)C(O)=O)N2C(N=CN=C3N)=C3N=C2
Molecular Formula
C15H23N7O5
Molecular Weight
381.39
Precautions
H302
References & Citations
[1]Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA (guanine-7-) -methyltransferase, mRNA (nucleoside-2'-) -methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253 (12) :4075-7.|[2]Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27 (1) :203-15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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