Sinefungin

• Description:

  Sinefungin is a potent inhibitor of virion mRNA (guanine-7-) -methyltransferase, mRNA (nucleoside-2'-) -methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].

• Product Name Alternative:

  Adenosyl-Ornithine; A-9145; Antibiotic 32232RP

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Antibiotic; Fungal; Histone Methyltransferase; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Epigenetics

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/sinefungin.html

• Purity:

  99.79

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O[C@H]([C@@H]1O)[C@@H](O[C@@H]1C[C@@H](N)CC[C@H](N)C(O)=O)N2C(N=CN=C3N)=C3N=C2

• Molecular Formula:

  C15H23N7O5

• Molecular Weight:

  381.39

• Precautions:

  H302

• References & Citations:

  [1]Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA (guanine-7-) -methyltransferase, mRNA (nucleoside-2'-) -methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253 (12) :4075-7.|[2]Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27 (1) :203-15.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [58944-73-3]