Products for Research Use Only
RegisterLogin

DB18

CAT: 0804-HY-131978-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-131978-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DB18 is a potent and selective inhibitor of CDC2-like kinases (CLKs), with IC50 values in the range of 10-30 nM for CLK1, CLK2 and CLK4. DB18 has anti-tumor activity[1].
CAS Number
2587177-94-2
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db18.html
Purity
98.27
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC=C(C([N+]([O-])=O)=C1)N2C=C(N=N2)COC3=CC=CC4=C3N=C(N=C4)NC5=CC=CC(Cl)=C5
Molecular Formula
C24H18ClN7O3
Molecular Weight
487.90
References & Citations
[1]Brahmaiah D, et al. Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase. Bioorg Med Chem. 2021 Feb 1;31:115962.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T86165-01DB18

Popular Products