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Licarin B

CAT: 0804-HY-N0479-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0479-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway[1][2][3].
CAS Number
51020-87-2
Product Name Alternative
(-) -Licarin B
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GLUT; PPAR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/licarin-b.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(O[C@@H](C2=CC=C3C(OCO3)=C2)[C@@H]4C)C4=CC(/C=C/C)=C1
Molecular Formula
C20H20O4
Molecular Weight
324.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim YB, et al. The crystal structure of licarin-B, (C20H20O4), a component of the seeds of Myristica fragrans. Arch Pharm Res. 1991 Mar;14 (1) :1-6.|[2]Cao GY, et al. New inhibitors of nitric oxide production from the seeds of Myristica fragrans. Food Chem Toxicol. 2013 Dec;62:167-71.|[3]G. L. Shyni, et al. Licarin B from Myristica fragrans improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway in 3T3-L1 adipocytes. RSC Adv. 2016.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GLUT4; PPARγ

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