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TH588

CAT: 0804-HY-12814-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12814-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM) .
CAS Number
1609960-31-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TH588.html
Purity
99.20
Solubility
DMSO : 16 mg/mL (ultrasonic; warming)
Smiles
NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1
Molecular Formula
C13H12Cl2N4
Molecular Weight
295.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508 (7495) :215-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

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B5845-5.1TH588
T60984-01TH588 hydrochloride
A15537-2TH588 2mg
A15537-100TH588 100mg
A15537-50TH588 50mg
A15537-10TH588 10mg

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