AA3-DLin

• UNSPSC Description:

  AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs). AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model[1].

• Target Antigen:

  Liposome

• Type:

  Oligonucleotides

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/aa3-dlin.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCCCC/C=C\C/C=C\CCCCCCCC(OCCN1CCN(CC1)CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O

• Molecular Weight:

  699.10

• References & Citations:

  [1]Li Z, et al. Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines. ACS Nano. 2022 Nov 22;16(11):18936-18950.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  3027565-91-6