AA3-DLin

• Description :

  AA3-DLin is an ionizable cationic lipid with a pKa value of 5.8. AA3-DLin is used to delivery mRNA combined with lipid nanoparticles (LNPs) . AA3-DLin LNP COVID-19 vaccines encapsulating SARS CoV-2 spike mRNAs successfully induces strong immunogenicity in a BALB/c mouse model[1].

• UNSPSC :

  12352211

• Target :

  Liposome

• Type :

  Oligonucleotides

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/aa3-dlin.html

• Concentration :

  35.76 mM * 200 μL in Ethanol

• Purity :

  99.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CCCCC/C=C\C/C=C\CCCCCCCC(OCCN1CCN(CC1)CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O

• Molecular Formula :

  C44H78N2O4

• Molecular Weight :

  699.10

• References & Citations :

  [1]Li Z, et al. Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines. ACS Nano. 2022 Nov 22;16 (11) :18936-18950.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Solution, -20°C, 2 years

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  No Development Reported

• CAS Number :

  [3027565-91-6]