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Itacitinib adipate

CAT: 0804-HY-16997A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16997A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.
CAS Number
1334302-63-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Itacitinib_adipate.html
Purity
99.18
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1.O=C(O)CCCCC(O)=O
Molecular Formula
C32H33F4N9O5
Molecular Weight
699.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Griesshammer M, et al. The BCR-ABL1-negative myeloproliferative neoplasms: a review of JAK inhibitors in the therapeutic armamentarium. Expert Opin Pharmacother. 2017 Dec;18 (18) :1929-1938.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
JAK1

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