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VUBI1

CAT: 0804-HY-111671-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111671-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VUBI1 (SOS1 activator 1) is a benzimidazole derivative and SOS1 activator with a Kd of 44 nM. VUBI1 can significantly activate RAS-GTP and regulate the phosphorylation of ERK. VUBI1 also can serve as a target ligand for synthesizing PROTACs, such as PROTAC SOS1 degrader-1 , to induce SOS1 degradation. VUBI1 can be used in the study of cancer[1][2][3][4].
CAS Number
2245237-53-8
Product Name Alternative
SOS1 activator 1
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; PERK; Ras; SOS1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-activator-1.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
CN1CCN(C2=C3C(N(CC4=CC(C)=C(F)C(C)=C4)C(N5CC6(CNC6)C5)=N3)=CC(Cl)=C2)CC1
Molecular Formula
C26H32ClFN6
Molecular Weight
483.02
References & Citations
[1]Timothy R Hodges, et al. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61 (19) :8875-8894.|[2]Zhou C, et al. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. J Med Chem. 2022 Mar 10;65 (5) :3923-3942.|[3]Stickler S, et al. Targeting KRAS in pancreatic cancer. Oncol Res. 2024 Apr 23;32 (5) :799-805.|[4]Hamilton G, et al. Targeting of SOS1: from SOS1 Activators to Proteolysis Targeting Chimeras. Curr Pharm Des. 2023;29 (22) :1741-1746.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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