Napabucasin

• Description :

  Napabucasin (BBI608) is a STAT3 inhibitor which blocks stem cell activity in cancer cells.

• Product Name Alternative :

  BBI608

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  STAT

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Napabucasin.html

• Purity :

  99.94

• Solubility :

  DMSO : 4.44 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL|N-Methylpyrrolidone (NMP) : 16.67 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C2OC(C(C)=O)=C1)C3=C(C2=O)C=CC=C3

• Molecular Formula :

  C14H8O4

• Molecular Weight :

  240.21

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Zhang Y, et al. Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin. Cancer Med. 2016 Jun;5 (6) :1251-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  STAT3

• CAS Number :

  [83280-65-3]