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MUC-1 Antibody

CAT: 0013-GTR18717145Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18717145Size:100 µg
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Description
MAb VU-2G7 reacts with MUC1/Mucin-1/Epithelial Marker Antigen/EMA, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of VU-2G7 has not been established with epitope fingerprinting. The extra cellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is up regulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion.
UniProt
P15941
Reactivity
Human
Immunogen
A synthetic glycosylated MUC1 60mer tandem repeat NH2- (HGVTSAPDT (GalNAc) RPAPGSTAPPAHG) 3- COOH was used as the immunogen for the MUC-1 antibody.
Clonality
Monoclonal
Clone
VU-2G7
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein G affinity chromatography
Dilution
ELISA: order BSA/sodium azide-free format for coating
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the MUC-1 antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min
Tested Applications
ELISA
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG1, kappa

UniProtKB · P15941

Mucin-1

MUC1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15941
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MUC1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MUC-1
EC number
—
Processing
Precursor
Secondary accessions
A5YRV1, A6ZID9, A6ZIE0, B1AVQ8, B1AVR0, B6ECA1, E7ESE5, E7EUG9, P13931, P15942, P17626, Q0VAP5, Q0VAP6, Q14128, Q14876, Q16437, Q16442, Q16615, Q6S4Y3, Q7Z547, Q7Z548, Q7Z550, Q7Z552, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Autocatalytic cleavageDisulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Cellular component

Cell membraneCytoplasmMembraneNucleusSecreted

Domain

RepeatSignalTransmembraneTransmembrane helix

Disease

Tumor suppressor

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