PAX5 Antibody

CAT: 0013-GTR18717128Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18717128Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding domain, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis; therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.

UniProt

Q02548

Reactivity

Human

Immunogen

Full length human recombinant protein was used as the immunogen for this PAX5 antibody.

Clonality

Monoclonal

Clone

PCRP-PAX5-1B1

Conjugation

Unconjugated

Field of Research

Neuroscience

Purification

Protein G affinity chromatography

Dilution

Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT, Western bot: 2-4ug/ml

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the PAX5 antibody to be titered up or down for optimal performance.

Tested Applications

IHC-P, WB

Host or Source

Mouse

Preservative

1 mg/ml in 1X PBS; rAlbumin free, sodium azide free

Isotype

Mouse IgG1, kappa

UniProtKB · Q02548

Paired box protein Pax-5

PAX5_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q02548
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PAX5
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A3QVP6, A3QVP7, A3QVP8, C0KTF6, C0KTF7, C0KTF8, C0KTF9, C0KTG0, O75933, Q5SFM2, Q6S728, Q6S729, Q6S730, Q6S731, Q6S732

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Molecular function

Developmental proteinDNA-binding

Biological process

DifferentiationNeurogenesisSpermatogenesisTranscriptionTranscription regulation

Disease

Disease variantProto-oncogene

PTM

Glycoprotein

Cellular component

Nucleus

Domain

Paired box

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Alternative Products

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abx405116-01	Paired Box PAX5 (PAX5) Antibody
70R-50174	PAX5 antibody