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CEA Antibody / CEACAM5

CAT: 0013-GTR18717088-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18717088-01Size:20 µg
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Description
This antibody recognizes proteins of 80-200kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This MAb does not react with nonspecific cross-reacting antigen (NCA) and with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+) . Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix.
UniProt
P06731
Reactivity
Human
Immunogen
Human CEA/CECAM5 protein was used as the immunogen for the CEA antibody.
Clonality
Monoclonal
Clone
CEACAM5/12673
Conjugation
Unconjugated
Field of Research
Cancer Biology; Cell Biology
Purification
Protein A/G affinity
Dilution
Western blot: 2-4ug/ml, Immunohistochemistry: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the CEA antibody should be determined by the researcher.
Tested Applications
IHC-P, WB
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG, kappa

UniProtKB · P06731

Cell adhesion molecule CEACAM5

CEAM5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06731
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CEACAM5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
H9KVA7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCell adhesion

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinGPI-anchorLipoprotein

Domain

Immunoglobulin domainRepeatSignal

Disease

Oncogene

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