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HSD17B13 Antibody

CAT: 0013-GTR18716905-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18716905-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) is an enzyme in the liver that is associated with lipid droplets. It is encoded by the HSD17B13 gene in humans. HSD17B13 levels increase in patients with non-alcoholic fatty liver disease (NAFLD) and can enhance lipogenesis. However, some studies have shown that loss-of-function variants in HSD17B13 may protect against the progression of NAFLD to non-alcoholic steatohepatitis, fibrosis, and hepatocellular carcinoma.
UniProt
Q7Z5P4
Reactivity
Human
Immunogen
A portion of amino acids 1-200 of the human protein was used as the immunogen for the HSD17B13 antibody.
Clonality
Monoclonal
Clone
HSD17B13/13101
Conjugation
Unconjugated
Field of Research
Metabolism Research
Purification
Protein G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the HSD17B13 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG2b, kappa

UniProtKB · Q7Z5P4

17-beta-hydroxysteroid dehydrogenase 13

DHB13_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q7Z5P4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HSD17B13
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
17-beta-HSD 13
EC number
1.1.1.-, 1.1.1.62
Processing
Precursor
Secondary accessions
A8K9R9, Q2M1L5, Q86W22, Q86W23
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmEndoplasmic reticulumLipid droplet

Biological process

Lipid metabolism

Ligand

NAD

Molecular function

Oxidoreductase

PTM

Phosphoprotein

Domain

Signal

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