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Recombinant BAX Antibody

CAT: 0013-GTR18716810Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18716810Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 21kDa, identified as the Bax protein. This MAb is highly specific to Bax and shows no cross-reaction with Bcl-2 or Bcl-X protein. Bcl-2 blocks cell death following a variety of stimuli. Bax has extensive amino acid homology with Bcl-2 and it homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
UniProt
Q07812
Reactivity
Human
Immunogen
A portion of amino acids 1-100 from human BAX protein was used as the immunogen for the recombinant BAX antibody.
Clonality
Recombinant
Clone
RBAX/962
Conjugation
Unconjugated
Purification
Protein G affinity
Dilution
Western blot: 2-4ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant BAX antibody should be determined by the researcher.
Tested Applications
WB
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG1, kappa

UniProtKB · Q07812

Apoptosis regulator BAX

BAX_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q07812
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BAX
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K4W1, P55269, Q07814, Q07815, Q8WZ49, Q9NR76, Q9NYG7, Q9UCZ6, Q9UCZ7, Q9UQD6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisHost-virus interaction

Cellular component

CytoplasmMembraneMitochondrionMitochondrion outer membraneNucleus

Domain

TransmembraneTransmembrane helix

Disease

Tumor suppressor

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