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MC3138

CAT: 0804-HY-160818-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160818-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine significantly inhibits tumor growth in mice[1].
CAS Number
1844889-12-8
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc3138.html
Purity
99.27
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1=CN(C(C2=CC=CC=C2)=O)C=C(C1C3=CC(OC)=CC=C3)C(OCC)=O)OCC
Molecular Formula
C25H25NO6
Molecular Weight
435.47
References & Citations
[1]Hu T, et al. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 Nov;161 (5) :1584-1600.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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