TNO211

• Description :

  TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu (EDANS) -Ala-Lys-NH2) is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 can specifically detect MMP activity (Ex/Em = 340/485 nm) [1].

• CAS Number :

  [193475-71-7]

• Product Name Alternative :

  Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu (EDANS) -Ala-Lys-NH2

• UNSPSC :

  12352209

• Target :

  Fluorescent Dye; MMP

• Type :

  Peptides

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/tno211.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(O)(C1=CC=CC2=C1C=CC=C2NCCNC(CC[C@@H](C(N[C@@H](C)C(N[C@H](C(N)=O)CCCCN)=O)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CCC(N)=O)NC([C@H]3N(CCC3)C(CCCNC(C4=CC=C(C=C4)/N=N/C5=CC=C(C=C5)N(C)C)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C63H88N16O14S

• Molecular Weight :

  1325.54

• References & Citations :

  [1]Beekman B, et al. Convenient fluorometric assay for matrix metalloproteinase activity and its application in biological media. FEBS Lett. 1996 Jul 22;390 (2) :221-5.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported