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CETN1 Antibody / Centrin 1

CAT: 0013-GTR18717069-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18717069-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EF-hand type Ca2+-binding proteins consists of several family members, including Centrin-1, Centrin-2 and Centrin-3. The Centrin proteins are ubiquitously expressed cytoskeletal components that show increased expression during cell differentiation. Tissues where cilia are present, such as the retina and testis, express both Centrin-1 and -2, but Centrin-2 is also expressed in nondifferentiated, nonciliated retinal cells (retinoblastoma cells), liver, skeletal muscle, and cardiac muscle. In these tissues, Centrin associates with the centrosomes, mitotic spindle poles, and basal bodies. Knockdown studies reveal a requirement for Centrin in centriole duplication and organization of spindle pole morphology and the completion of cytokinesis. Centrin-3 plays a role in centrosome reproduction.
UniProt
Q12798
Reactivity
Human
Immunogen
A portion of amino acids 1-172 from human CETN1 protein was used as the immunogen for the CETN1 antibody.
Clonality
Monoclonal
Clone
CETN1/9878
Conjugation
Unconjugated
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the CETN1 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG

UniProtKB · Q12798

Centrin-1

CETN1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q12798
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CETN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R536
Protein keywords

Ligand

CalciumMetal-binding

Biological process

Cell cycleCell divisionMitosis

Cellular component

Cell projectionCytoplasmCytoskeleton

Technical term

Proteomics identificationReference proteome

Domain

Repeat

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