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BIRC5 Antibody / Survivin

CAT: 0013-GTR18716909-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18716909-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The baculovirus protein p35 inhibits virally induced apoptosis of invertebrate and mammalian cells and may function to impair the clearing of virally infected cells by the host s immune system. This is accomplished at least in part by its ability to block both TNF- and FAS-mediated apoptosis through the inhibition of the ICE family of serine proteases. Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino terminal baculovirus IAP repeat (BIR) motif and a carboxy terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivin-microtubule interactions occurs.
UniProt
O15392
Reactivity
Human
Immunogen
A portion of amino acids 1-142 from human BIRC5 protein was used as the immunogen for the BIRC5 antibody.
Clonality
Monoclonal
Clone
BIRC5/9073
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein G affinity
Dilution
Western blot: 2-4ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the BIRC5 antibody should be determined by the researcher.
Tested Applications
WB
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · O15392

Baculoviral IAP repeat-containing protein 5

BIRC5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15392
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BIRC5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A2SUH6, B2R4R1, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCell cycleCell divisionChromosome partitionHost-virus interactionMitosisTranscriptionTranscription regulation

Cellular component

CentromereChromosomeCytoplasmCytoskeletonKinetochoreMicrotubuleNucleus

Ligand

Metal-bindingZinc

Molecular function

Protease inhibitorRepressorThiol protease inhibitor

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