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Zongertinib

CAT: 0804-HY-148810-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148810-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zongertinib (BI 1810631) is a potent and selective HER2 and EGFR tyrosine kinase inhibitor with IC50 values of 13 nM and 579 nM, respectively. Zongertinib has antitumor activity and can be used in the study of multiple solid tumors[1][2][3].
CAS Number
2728667-27-2
Product Name Alternative
BI 1810631
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zongertinib.html
Purity
99.74
Solubility
DMSO : 30.77 mg/mL (ultrasonic; warming; adjust pH to 7 with 1 M HCL; heat to 60°C)
Smiles
O=C(NC1CCN(CC1)C2=NC=C3N=CN=C(C3=N2)NC4=CC=C(C(C)=C4)OC5=CC(N=CN6C)=C6C=C5)C=C
Molecular Formula
C29H29N9O2
Molecular Weight
535.60
Precautions
H302, H315, H319, H335
References & Citations
[1]WHO Drug Informat ion - World Health Organization (WHO) .|[2]Wilding Birgit, et al. Synthesis of diazino-pyrimidines as anticancer agents: World Intellectual Property Organization, WO2021213800. 2021-10-28.|[3]Li S, et al. Emerging Targeted Therapies in Advanced Non-Small-Cell Lung Cancer. Cancers (Basel) . 2023 May 24;15 (11) :2899.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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