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CAT: 0013-GTR18712522-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR18712522-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ONC-841 is a humanized monoclonal antibody targeting Sialic acid-binding Ig-like lectin 10 (Siglec-10) . Siglec-10 is an inhibitory receptor expressed on the surface of macrophages that triggers a "don't eat me" signal upon binding to CD24 on tumor cells, thereby inhibiting phagocytosis. ONC-841 specifically binds to Siglec-10 and blocks the CD24-Siglec-10 interaction, alleviating immune suppression and enhancing the phagocytic clearance of tumor cells by macrophages. This antibody is significant for immunotherapy research in solid tumors with high CD24 expression, such as ovarian and breast cancers.
Target
Others
Clonality
Monoclonal
Conjugation
Unconjugated
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.

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