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CCT020312

CAT: 0804-HY-119240-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119240-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells.
CAS Number
324759-76-4
Product Name Alternative
2'-3'-cyclic GMP-AMP
UNSPSC
12352005
Target
Autophagy; PERK
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CCT020312.html
Concentration
10mM
Purity
99.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C(C3=CC=CC=C3)=C1C4=NN(C(C4)C5=CC=C(C=C5)Br)C(CCN(CC)CC)=O)C=C(C=C2)Br
Molecular Formula
C31H30Br2N4O2
Molecular Weight
650.40
References & Citations
[1]Stockwell SR, et al.Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS One. 2012;7 (1) :e28568.|[2]Bruch J, et al. PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med. 2017 Mar;9 (3) :371-384.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
BA3586-5.1CCT020312
A19137-50CCT020312 50mg
A19137-100CCT020312 100mg
A19137-25CCT020312 25mg
A19137-1CCT020312 1mg
A19137-500CCT020312 500mg
A19137-10CCT020312 10mg
A19137-5CCT020312 5mg
A19137-10mM-DCCT020312 10mM * 1mL in DMSO

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