N-Nitrosomorpholine

• Description:

  N-Nitrosomorpholine is a photosensitive nitrosamine that is carcinogenic and can be used to construct animal cancer models[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H351

• Target:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/n-nitrosomorpholine.html

• Purity:

  99.98

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=NN1CCOCC1

• Molecular Formula:

  C4H8N2O2

• Molecular Weight:

  116.12

• Precautions:

  H301, H351

• References & Citations:

  [1]K D Brunnemann, et al. N-Nitrosomorpholine and Other Volatile N-nitrosamines in Snuff Tobacco. Carcinogenesis. 1982;3 (6) :693-6.|[2]Kobusch AB, et al. Tumor-promoting activity and cytotoxicity of 3,4,3',4'-tetrachlorobiphenyl on N-nitrosomorpholine-induced murine liver foci. J Cancer Res Clin Oncol. 1989;115 (3) :247-52.|[3]Enzmann H, et al. Elevation of glucose-6-phosphate in early stages of hepatocarcinogenesis induced in rats by N-nitrosomorpholine. Horm Metab Res. 1988 Feb;20 (2) :128-9.|[4]Weber E, et al. Dose and time dependence of the cellular phenotype in rat hepatic preneoplasia and neoplasia induced by continuous oral exposure to N-nitrosomorpholine. Carcinogenesis. 1994 Jun;15 (6) :1235-42.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [59-89-2]