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Isecarosmab

CAT: 0804-HY-P99671-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99671-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a KD value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life[1][2][3].
CAS Number
2254082-79-4
Product Name Alternative
M-6495
UNSPSC
12352203
Target
ADAMTS
Type
Inhibitory Antibodies
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isecarosmab.html
Purity
96.95
Solubility
10 mM in DMSO
Smiles
[Isecarosmab]
Molecular Weight
(28.89 kDa)
References & Citations
[1]Siebuhr AS, et al. The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo. Int J Mol Sci. 2020 Aug 20;21 (17) :5992. |[2]Sharma N, et al. Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors. Osteoarthritis Cartilage. 2020 May;28 (5) :658-668. |[3]C. Brenneis. Structural and symptomatic benefit of a half-live extended, systemically applied anti-ADAMTS-5 inhibitor (M6495) . 2018. 26 (1), S299-S300.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 1

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