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QNZ46

CAT: 0804-HY-15703-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15703-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
QNZ46 is a highly selective noncompetitive NMDA receptor antagonist targeting GluN2C/D (IC50=3.9 μM), GluN1/GluN2C (IC50=7.1 μM), and GluN1/GluN2D (IC50=182 μM) subunits. QNZ46 inhibits glutamate-mediated calcium influx, thereby blocking excitotoxicity. QNZ46 is membrane permeable and can cross the blood-brain barrier, where it inhibits myelin damage and axonal degeneration[1][2][3].
CAS Number
1237744-13-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/QNZ46.html
Purity
99.46
Solubility
DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C1=CC=C(N2C(/C=C/C3=CC=CC([N+]([O-])=O)=C3)=NC4=C(C=C(OC)C=C4)C2=O)C=C1
Molecular Formula
C24H17N3O6
Molecular Weight
443.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Hansen KB, et al. Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci. 2011 Mar 9;31 (10) :3650-3661.|[2]Doyle S, et al. Vesicular glutamate release from central axons contributes to myelin damage. Nat Commun. 2018 Mar 12;9 (1) :1032.|[3]Guo F, et al. Sevoflurane acts as an antidepressant by suppression of GluN2D-containing NMDA receptors on interneurons. Br J Pharmacol. 2024 Sep;181 (18) :3483-3502.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor

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