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GET73

CAT: 0804-HY-108034-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108034-01Size:5 mg
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Description
GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3].
CAS Number
202402-01-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/get73.html
Concentration
10mM
Purity
98.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(C(F)(F)F)C=C1)CCCOC
Molecular Formula
C13H16F3NO2
Molecular Weight
275.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51 (2) :128-35.|[2]Ferraro L, et al. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63 (6) :1359-71.|[3]Loche A, et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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MBS3847181-01GET73
A22683-1GET73 1mg
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A22683-25GET73 25mg
A22683-5GET73 5mg
A22683-200GET73 200mg
A22683-50GET73 50mg
A22683-10GET73 10mg
A22683-10mM-DGET73 10mM * 1mL in DMSO

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