Recombinant Human HspA9

• Description:

  Recombinant Human HspA9

• Product Name Alternative:

  Hsp70 protein 9

• Gene Name:

  HSPA9

• UniProt:

  P38646

• Cellular Locus:

  Mitochondrion , Nucleus, nucleolus

• Reactivity:

  Human

• Target Antigen:

  Stress-70 protein, mitochondrial

• Target:

  HspA9

• Type:

  Protein

• Applications:

  WB

• Concentration:

  Lot Specific

• Dilution:

  Dilute in PBS or medium that is identical to that used in the assay system.

• Form:

  Liquid

• Buffer:

  20 mM Tris

• Function:

  Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583). Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583). May play a role in the control of cell proliferation and cellular aging (By similarity). {UniProtKB:P38647, PubMed:21123823, PubMed:26702583}.

• Storage Conditions:

  Store at 4°C if entire vial will be used within 2-4 weeks. Store at or below - 20°C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA is recommended for long-term storage.

• Specificity:

  HspA9

• Formulation:

  Sterile-filtered colorless solution in 20mM Tris-Hcl, pH 8.0, 0.5mM DTT and 10% glycerol.

• Buffer pH:

  pH 8.0

• Target Background:

  HspA9, a memer of the Hsp70 family, encodes a heat-shock cognate protein that is involved in the control of cell proliferation and acts as a chaperone. HspA9 is located on chromosome 5, band q31, a region thatis often deleted in myeloid leukemias and myelodysplasia, making it a candidate tumor suppressor gene. HspA9 suppresses nuclear translocation, transcriptional activation, and control centrosome-duplication functions of p53.

• CAS Number:

  9000-83-3