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N-Acetylputrescine hydrochloride

CAT: 0804-HY-113100-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113100-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N-Acetylputrescine hydrochloride is a polyamine metabolite that regulates cell proliferation and signal transduction mainly by participating in polyamine acetylation modification. N-Acetylputrescine hydrochloride may reduce the positive charge of polyamines, affect protein-nucleic acid interactions, and promote cell growth. The concentration changes of N-Acetylputrescine hydrochloride can help disease diagnosis (such as early screening and efficacy evaluation of lung cancer) and microbial cell wall structure research. N-Acetylputrescine hydrochloride can be used as a potential biomarker for the progression of squamous cell carcinoma of the lung (SCCL) and Parkinson's disease (PD) [1][2][3][4].
CAS Number
18233-70-0
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/N-Acetylputrescine_hydrochloride.html
Purity
99.0
Solubility
DMSO : ≥ 125 mg/mL|H2O : 200 mg/mL (ultrasonic)
Smiles
CC(NCCCCN)=O.Cl
Molecular Formula
C6H15ClN2O
Molecular Weight
166.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Pfanzagl B, et al. N-acetylputrescine as a characteristic constituent of cyanelle peptidoglycan in glaucocystophyte algae. J Bacteriol. 1996 Dec;178 (23) :6994-7.|[2]Menashe M, et al. Formulation of N-acetylputrescine and N1-acetylspermidine in cultured human lymphocytes. Biochem J. 1980 Apr 15;188 (1) :263-7.|[3]Liu R, et al. Plasma N-acetylputrescine, cadaverine and 1,3-diaminopropane: potential biomarkers of lung cancer used to evaluate the efficacy of anticancer drugs. Oncotarget. 2017 Jul 17;8 (51) :88575-88585.|[4]Peng K W, et al. Identification and Validation of N-Acetylputrescine in Combination With Non-Canonical Clinical Features As a Parkinson's Disease Biomarker Panel[J]. bioRxiv, 2021: 2021.07. 23.453542.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Phase 2
Isoform
Human Endogenous Metabolite; Microbial Metabolite

Chemical Information

Monoacetyl-1,4-diaminobutane hydrochloride
CAS Number18233-70-0
PubChem CID12471560
IUPAC NameN-(4-aminobutyl)acetamide;hydrochloride
Molecular FormulaC6H15ClN2O
Molecular Weight166.65
Topological Polar Surface Area55.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Heavy Atom Count10
Formal Charge0
Complexity83
SMILES
CC(=O)NCCCCN.Cl
InChI
InChI=1S/C6H14N2O.ClH/c1-6(9)8-5-3-2-4-7;/h2-5,7H2,1H3,(H,8,9);1H
InChIKey
XBECFEJUQZXMFE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Monoacetyl-1,4-diaminobutane hydrochloride
CAS: 18233-70-0
CID: 12471560
Formula: C6H15ClN2O
MW: 166.65
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight166.65
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count2
Rotatable Bond Count4
Exact Mass166.0872908
Monoisotopic Mass166.0872908
Topological Polar Surface Area55.1 Ų
Heavy Atom Count10
Formal Charge0
Complexity83.1
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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