Taltobulin

CAT: 0804-HY-15584-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15584-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis[1].
CAS Number
[228266-40-8]
Product Name Alternative
HTI-286; SPA-110
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload; Apoptosis; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/taltobulin.html
Purity
99.90
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C)(C)[C@H](NC([C@H](C(C)(C1=CC=CC=C1)C)NC)=O)C(N([C@@H](C(C)C)/C=C(C(O)=O)\C)C)=O
Molecular Formula
C27H43N3O4
Molecular Weight
473.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63 (8) :1838-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
Phase 1
Isoform
Traditional Cytotoxic Agents

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