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MNI137

CAT: 0804-HY-103572-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103572-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization[1].
CAS Number
946619-21-2
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mni137.html
Purity
95.0
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=NC=CC(C2=NC3=CC=C(Br)C=C3NC(C2)=O)=C1
Molecular Formula
C15H9BrN4O
Molecular Weight
341.16
References & Citations
[1]Hemstapat K, et al. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007;322 (1) :254-264.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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