ACA-28

• Description:

  ACA-28 is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth and induces apoptosis. ACA-28 can activate nuclear factor erythroid 2-related factor 2 (Nrf2) signaling via inducing ROS production. ACA-28 can be used for the research of cancer, such as melanoma [1][2].

• UNSPSC:

  12352005

• Target:

  Apoptosis; ERK; Keap1-Nrf2; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/aca-28.html

• Concentration:

  10mM

• Purity:

  99.70

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(OC)OC1=CC=C(C(C2=CC=CC=C2)OC(OC)=O)C=C1

• Molecular Formula:

  C17H16O6

• Molecular Weight:

  316.31

• References & Citations:

  [1]Satoh R, et al. Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28. Bioorg Chem. 2020 Oct;103:104137. |[2]Takasaki T, et al. ACA-28, an ERK MAPK Signaling Modulator, Exerts Anticancer Activity through ROS Induction in Melanoma and Pancreatic Cancer Cells. Oxid Med Cell Longev. 2024 Mar 11;2024:7683793.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  948044-25-5