ACA-28

CAT: 0804-HY-147855-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-147855-01Size:5 mg
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Description
ACA-28 is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth and induces apoptosis. ACA-28 can activate nuclear factor erythroid 2-related factor 2 (Nrf2) signaling via inducing ROS production. ACA-28 can be used for the research of cancer, such as melanoma [1][2].
CAS Number
[948044-25-5]
UNSPSC
12352005
Target
Apoptosis; ERK; Keap1-Nrf2; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aca-28.html
Concentration
10mM
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC)OC1=CC=C(C(C2=CC=CC=C2)OC(OC)=O)C=C1
Molecular Formula
C17H16O6
Molecular Weight
316.31
References & Citations
[1]Satoh R, et al. Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28. Bioorg Chem. 2020 Oct;103:104137. |[2]Takasaki T, et al. ACA-28, an ERK MAPK Signaling Modulator, Exerts Anticancer Activity through ROS Induction in Melanoma and Pancreatic Cancer Cells. Oxid Med Cell Longev. 2024 Mar 11;2024:7683793.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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