Products for Research Use Only
RegisterLogin

ADTL-EI1712

CAT: 0804-HY-138215-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-138215-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo[1].
CAS Number
2414916-45-1
UNSPSC
12352005
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/adtl-ei1712.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(NC(C2=CC=CC=C2Cl)=O)SC3=C1CCN(C(NC4=CC=CC=C4Cl)=S)C3)N
Molecular Formula
C22H18Cl2N4O2S2
Molecular Weight
505.44
References & Citations
[1]Wang G, et al. Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types. J Med Chem. 2020 Apr 23;63 (8) :3976-3995.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-139742-01ADTL-SA1215
HY-121650ADTN
HY-121650AADTN (hydrobromide)
HY-109582-01ADT-OH
HY-177106-01ADT-1004
HY-157887-01ADT-007
HY-W097565SPyroxsulam Metabolite ADTP-d6
HY-109582R-01ADT-OH (Standard)

Alternative Products

CatalogName
BA6459-10ADTL-EI1712
BA4506-25ADTL-SA1215

Popular Products