Icilin

CAT: 0804-HY-11062-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-11062-01Size:5 mg
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Description
Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM) . Icilin is a "super-cooling agent" [1][2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response[3].
CAS Number
[36945-98-9]
Product Name Alternative
AG-3-5
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Icilin.html
Concentration
10mM
Purity
99.26
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=CC=C2O)CC=C(C3=CC=CC([N+]([O-])=O)=C3)N1
Molecular Formula
C16H13N3O4
Molecular Weight
311.29
Precautions
H302, H312, H332
References & Citations
[1]Huai-hu Chuang, et al. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron. 2004 Sep 16;43 (6) :859-69.|[2]Viktor V Feketa, et al. Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. Crit Care Med. 2014 May;42 (5) :e355-63.|[3]Benjamin W Ewanchuk, et al. The cooling compound icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response. FASEB J. 2018 Mar;32 (3) :1236-1249.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPM8

Alternative Products

CatalogName
M14271-01ICILIN
A13560-10Icilin 10mg
A13560-500Icilin 500mg
A13560-5Icilin 5mg
A13560-100Icilin 100mg
A13560-25Icilin 25mg

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