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Ampyrone

CAT: 0804-HY-B1398-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1398-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy[1][2][3].
CAS Number
83-07-8
Product Name Alternative
4-Aminophenazone
UNSPSC
12352005
Hazard Statement
H302
Target
COX; Drug Metabolite
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-Aminoantipyrine.html
Purity
99.72
Solubility
DMSO : ≥ 50 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=CC=C2)N(C)C(C)=C1N
Molecular Formula
C11H13N3O
Molecular Weight
203.25
Precautions
H302
References & Citations
[1]Berno CR, et al. 4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24.|[2]Keck CHC, et al. Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice. bioRxiv [Preprint]. 2025 Feb 27:2025.02.20.639185.|[3]Kalaskar, et al. Evaluation of ampyrone (4-aminoantipyrine), an activator of the intra-melanosomal domain of human tyrosinase, as a potential therapeutic agent for oculocutaneous albinism type 1B. Investigative Ophthalmology & Visual Science 63.7 (2022) : 676-F0130.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX

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