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JW67

CAT: 0804-HY-108442-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108442-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM[1]. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth[1].
CAS Number
442644-28-2
UNSPSC
12352005
Hazard Statement
H301
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jw67.html
Purity
98.15
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C2(OCC3(COC4(C5=CC=CC=C5NC4=O)OC3)CO2)C6=CC=CC=C6N1
Molecular Formula
C21H18N2O6
Molecular Weight
394.38
Precautions
H301
References & Citations
[1]Waaler J, et al. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 2011;71 (1) :197-205.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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