Pendimethalin

• Description :

  Pendimethalin is an orally active herbicide that controls annual grasses and certain broadleaf weeds. Pendimethalin induces Apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells[1][2][3][4].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H317, H400, H410

• Target :

  Apoptosis; Bcl-2 Family; Caspase; SOD

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/pendimethalin.html

• Purity :

  99.88

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=[N+](C1=C(NC(CC)CC)C([N+]([O-])=O)=C(C)C(C)=C1)[O-]

• Molecular Formula :

  C13H19N3O4

• Molecular Weight :

  281.31

• Precautions :

  H302, H317, H400, H410

• References & Citations :

  [1]Martin Kočárek, et al. Effect of adjuvant on pendimethalin and dimethenamid-P behaviour in soil. J Hazard Mater. 2018 Jul 15;354:266-274.|[2]Lee HS, et al. Pendimethalin induces apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells. Food Chem Toxicol. 2022 Oct;168:113370.|[3]Ansari SM, et al. Pendimethalin induces oxidative stress, DNA damage, and mitochondrial dysfunction to trigger apoptosis in human lymphocytes and rat bone-marrow cells. Histochem Cell Biol. 2018 Feb;149 (2) :127-141. |[4]Ahmad MI, et al. Pendimethalin-induced oxidative stress, DNA damage and activation of anti-inflammatory and apoptotic markers in male rats. Sci Rep. 2018 Nov 20;8 (1) :17139.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [40487-42-1]