Pendimethalin

• Description:

  Pendimethalin is an orally active herbicide that controls annual grasses and certain broadleaf weeds. Pendimethalin induces Apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H317, H400, H410

• Target:

  Apoptosis; Bcl-2 Family; Caspase; SOD

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/pendimethalin.html

• Purity:

  99.88

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=[N+] (C1=C (NC (CC) CC) C ([N+] ([O-]) =O) =C (C) C (C) =C1) [O-]

• Molecular Formula:

  C13H19N3O4

• Molecular Weight:

  281.31

• Precautions:

  H302, H317, H400, H410

• References & Citations:

  [1]Martin Kočárek, et al. Effect of adjuvant on pendimethalin and dimethenamid-P behaviour in soil. J Hazard Mater. 2018 Jul 15;354:266-274.|[2]Lee HS, et al. Pendimethalin induces apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells. Food Chem Toxicol. 2022 Oct;168:113370.|[3]Ansari SM, et al. Pendimethalin induces oxidative stress, DNA damage, and mitochondrial dysfunction to trigger apoptosis in human lymphocytes and rat bone-marrow cells. Histochem Cell Biol. 2018 Feb;149 (2) :127-141. |[4]Ahmad MI, et al. Pendimethalin-induced oxidative stress, DNA damage and activation of anti-inflammatory and apoptotic markers in male rats. Sci Rep. 2018 Nov 20;8 (1) :17139.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  40487-42-1