Mitonafide

CAT: 0804-HY-119182-04Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-119182-04Size:25 mg

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Description

Mitonafide (NSC 300288) is a cytostatic agent. Mitonafide binds to double-stranded DNA through intercalation, and inhibits DNA and RNA synthesis. Mitonafide is an antitumor agent that can be used in the research of cancers, such as non-small cell lung cancer (NSCLC), leukemia[1][2][3].

CAS Number

54824-17-8

Product Name Alternative

NSC 300288

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mitonafide.html

Purity

99.73

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C1N(C(C2=CC([N+]([O-])=O)=CC3=CC=CC1=C23)=O)CCN(C)C

Molecular Formula

C16H15N3O4

Molecular Weight

313.31

References & Citations

[1]Llombart M, et al. Phase I study of mitonafide in solid tumors. Invest New Drugs. 1992 Aug;10 (3) :177-81. |[2]inha BK, et al. Mechanism of DNA strand breaks by mitonafide, an imide derivative of 3-nitro-1,8-naphthalic acid. Biochem Pharmacol. 1985 Nov 1;34 (21) :3845-52. |[3] Rosell R, et al. Phase I study of mitonafide in 120 hour continuous infusion in non-small cell lung cancer. Invest New Drugs. 1992 Aug;10 (3) :171-5.|[4]Samanta S, et al. Antitumor activity of Nitronaphthal-NU, a novel mixed-function agent. J Exp Ther Oncol. 2005;5 (1) :15-22. |[5]Pain A, et al. Evaluation of naphthalmustine, a nitrogen mustard derivative of naphthalimide as a rationally-designed anticancer agent. J Exp Clin Cancer Res. 2003 Sep;22 (3) :411-8. |[6]Xin M, et al. Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents. Bioorg Med Chem Lett. 2020 Apr 15;30 (8) :127051.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Chemical Information

Mitonafide

Mitonafide is a small molecule drug. Mitonafide has a monoisotopic molecular weight of 313.11 Da.

CAS Number	54824-17-8
PubChem CID	327044
IUPAC Name	2-[2-(dimethylamino)ethyl]-5-nitrobenzo[de]isoquinoline-1,3-dione
Molecular Formula	C16H15N3O4
Molecular Weight	313.31
XLogP	2
Topological Polar Surface Area	86.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	23
Formal Charge	0
Complexity	516

SMILES

CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)[N+](=O)[O-]

InChI

InChI=1S/C16H15N3O4/c1-17(2)6-7-18-15(20)12-5-3-4-10-8-11(19(22)23)9-13(14(10)12)16(18)21/h3-5,8-9H,6-7H2,1-2H3

InChIKey

XXVLKDRPHSFIIB-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 54824-17-8

CID: 327044

Formula: C16H15N3O4

MW: 313.31

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	313.31
XLogP3	2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	313.10625597
Monoisotopic Mass	313.10625597
Topological Polar Surface Area	86.4 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	516
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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BA4050-100	Mitonafide

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Chemical Information

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