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Nialamide

CAT: 0804-HY-B1199-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1199-01Size:100 mg
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Description
Nialamide is a non-selective monoamine oxidase (MAO) inhibitor. Nialamide inhibits MAO and regulates ROS production. Nialamide induces hyperkinesis in animals, enhances the anticonvulsant effect of Diphenylhydantoin in mice, increases rectal temperature, and enhances the pressor effect of Norepinephrine. Nialamide can be used in the research of depression, inflammatory diseases, neurodegenerative diseases, and hypertension[1][2][3][4][5][6].
CAS Number
51-12-7
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H315, H319, H335, H351
Target
Monoamine Oxidase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Nialamide.html
Purity
96.29
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=CC=NC=C1)NNCCC(NCC2=CC=CC=C2)=O
Molecular Formula
C16H18N4O2
Molecular Weight
298.34
Precautions
H302+H312+H332, H315, H319, H335, H351
References & Citations
[1]Boldyrev AA, et al. Sources of reactive oxygen species production in excitotoxin- stimulated cerebellar granule cells. Biochem Biophys Res Commun. 1999 Mar 16;256 (2) :320-4. |[2]Lee H, et al. Ionizing radiation induced modification of nialamide as an anti inflammatory agent against lipopolysaccharide induced RAW 264.7 and DH82 cells. Exp Ther Med. 2024 Mar 11;27 (5) :192.|[3]Buus Lassen J. Nialamide-induced hypermotility in mice treated with inhibitors of monoamine uptake, 5-HT antagonists and lithium. Psychopharmacology (Berl) . 1989;98 (2) :257-61. |[4]DAVEY MJ, et al. The effects of nialamide on adrenergic functions. Br J Pharmacol Chemother. 1963 Feb;20 (1) :121-34.|[5]P'AN SY, et al. Anticonvulsant effect of nialamide and diphenylhydantoin. Proc Soc Exp Biol Med. 1961 Dec;108:680-3.|[6]Modigh K, et al. On the role of central nervous system catecholamines and 5-hydroxytryptamine in the nialamide-induced behavioural syndrome. Br J Pharmacol. 1972 Sep;46 (1) :32-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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