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Questin

CAT: 0804-HY-137990-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-137990-01Size:5 mg
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Description
Questin is an anthraquinone compound and antibacterial agent. Questin can be isolated from marine-derived fungi and plants. Questin inhibits Cdc25B phosphatase. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL. Questin displays antiprotozoal activity against the animal protozoan pathogen Tritrichomonas foetus, with a MIC of 12.5 µg/mL. Questin has anticancer activity against lung and colon cancer[1][2][3][4][5].
CAS Number
[3774-64-9]
UNSPSC
12352005
Target
Bacterial; Parasite; Phosphatase
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/questin.html
Purity
97.75
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C=C(O)C=C2OC)C(C3=CC(C)=CC(O)=C13)=O
Molecular Formula
C16H12O5
Molecular Weight
284.26
References & Citations
[1]Lei Guo, et al. Optimized production and isolation of antibacterial agent from marine Aspergillus flavipes against Vibrio harveyi. 3 Biotech. 2017 Dec;7 (6) :383.|[2]Choi SG, et al. Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb. Nat Prod Res. 2007 May 20;21 (6) :487-93.|[3]Gauthier T, et al. Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells. PLoS One. 2012;7 (2) :e29906.|[4]Liu N, et al. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301. Fitoterapia. 2019 Jun;135:27-32.|[5]Chaudhary NK, et al. Banksialactones and Banksiamarins: Isochromanones and Isocoumarins from an Australian Fungus, Aspergillus banksianus. J Nat Prod. 2018 Jul 27;81 (7) :1517-1526.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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