8-Chloroquinazolin-4-ol

• UNSPSC Description:

  8-Chloroquinazolin-4-ol (Compd 18) is a PARP-1 enzyme inhibitor, with an IC50 of 5.65 μM[1].

• Target Antigen:

  PARP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/8-chloroquinazolin-4-ol.html

• Purity:

  98.44

• Solubility:

  DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C1NC=NC2=C1C=CC=C2Cl

• Molecular Weight:

  180.594

• References & Citations:

  [1]Shridhar S Kulkarni, et al. Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors. Eur J Med Chem. 2012 Apr:50:264-73.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  101494-95-5