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KDU731

CAT: 0804-HY-103583-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103583-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo[1][2]. KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety[2].
CAS Number
1610610-48-4
UNSPSC
12352005
Target
Parasite; PI4K
Type
Reference compound
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/kdu731.html
Purity
99.52
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(C3=CC=C(C(N)=O)C=C3)C=NN2C=C1)N(C)C4=NC=C(C#N)C=C4
Molecular Formula
C22H16N6O2
Molecular Weight
396.40
References & Citations
[1]Ward HD, et al. New Tools for Cryptosporidium Lead to New Hope for Cryptosporidiosis. Trends Parasitol. 2017 Sep;33 (9) :662-664.|[2]Manjunatha UH, et al. A Cryptosporidium PI (4) K inhibitor is a drug candidate for cryptosporidiosis. Nature. 2017 Jun 15;546 (7658) :376-380.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI4K

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