Reticuline

• Description:

  Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1]. Reticuline exhibits cardiovascular effects[2].

• UNSPSC:

  12352005

• Hazard Statement:

  H301+H311+H331, H315, H319

• Target:

  Endogenous Metabolite; JAK; NF-κB; STAT

• Type:

  Natural Products

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/reticuline.html

• Purity:

  98.91

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC1=CC2=C (C=C1OC) CCN (C) [C@H]2CC3=CC=C (OC) C (O) =C3

• Molecular Formula:

  C19H23NO4

• Molecular Weight:

  329.39

• Precautions:

  H301+H311+H331, H315, H319

• References & Citations:

  [1]Yang X, et al. Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways. Planta Med. 2018 Jan;84 (1) :20-25.|[2]Katy Lísias Dias, et al. Cardiovascular effects induced by reticuline in normotensive rats. Planta Med. 2004 Apr;70 (4) :328-33.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite; JAK2; NF-κB; STAT3

• CAS Number:

  485-19-8