Reticuline

CAT: 0804-HY-N1356-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N1356-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3[1]. Reticuline exhibits cardiovascular effects[2].
CAS Number
[485-19-8]
UNSPSC
12352005
Hazard Statement
H301+H311+H331, H315, H319
Target
Endogenous Metabolite; JAK; NF-κB; STAT
Type
Natural Products
Related Pathways
Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/reticuline.html
Purity
98.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(C=C1OC)CCN(C)[C@H]2CC3=CC=C(OC)C(O)=C3
Molecular Formula
C19H23NO4
Molecular Weight
329.39
Precautions
H301+H311+H331, H315, H319
References & Citations
[1]Yang X, et al. Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways. Planta Med. 2018 Jan;84 (1) :20-25.|[2]Katy Lísias Dias, et al. Cardiovascular effects induced by reticuline in normotensive rats. Planta Med. 2004 Apr;70 (4) :328-33.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; JAK2; NF-κB; STAT3

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