Methylstat

• UNSPSC Description:

  Methylstat is a potent histone demethylases inhibitor. Methylstat shows anti-proliferative activity with low cytotoxicity. Methylstat induces apoptosis and cell cycle arrest at G0/G1 phase. Methylstat increases the expression of p53 and p21 protein levels. Methylstat inhibits angiogenesis induced by various cytokines. Methylstat can be used as a chemical probe for addressing its role in angiogenesis[1][2].

• Target Antigen:

  Apoptosis; Histone Demethylase; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/methylstat.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  COC(/C=C/C(N(O)CCCCNCC(C=C1)=CC=C1COC(NC2=CC=CC3=C2C=CC=C3)=O)=O)=O

• Molecular Weight:

  505.56

• References & Citations:

  [1]Yumi Cho, et al. A histone demethylase inhibitor, methylstat, inhibits angiogenesis in vitro and in vivo. RSC Advances, 2014.|[2]Kacı FN, et al. Synergistic Apoptotic Effects of Bortezomib and Methylstat on Multiple Myeloma Cells. Arch Med Res. 2020 Apr;51(3):187-193.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1310877-95-2