Ulocuplumab

CAT: 0804-HY-P99272-01Size: 1 mgDry Ice: YesHazardous: No
CAT#:0804-HY-P99272-01Size:1 mg
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Description
Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL) . Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models[1][2].
CAS Number
[1375830-34-4]
Product Name Alternative
BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody
UNSPSC
12352203
Target
CXCR
Type
Inhibitory Antibodies
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ulocuplumab.html
Purity
99.90
Solubility
10 mM in DMSO
Smiles
[Ulocuplumab]
Molecular Weight
(144.84 kDa)
References & Citations
[1]Kashyap MK, et al. Ulocuplumab (BMS-936564 / MDX1338) : a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway. Oncotarget. 2016 Jan 19;7 (3) :2809-22. |[2]Kuhne MR, et al. BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. Clin Cancer Res. 2013 Jan 15;19 (2) :357-66.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3
Isoform
CXCR4

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